Never delay or disregard seeking professional medical advice from your doctor or another qualified healthcare provider because of something you have read on SelfHacked. Researchers hope that one day monolaurin could be used to create a new antibiotic or antiviral medication thats effective against a broad spectrum of microbes. 2014 Apr 1; 306(7):E838-47. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. Furthermore, monolaurin has been shown to possess additive benefits, meaning when monolaurin is combined with other compounds health benefits are also increased [Ref # 20, 21]. Antibacterial interactions of monolaurin with commonly used antimicrobials and food components [Abstract]. A 2013 study published in the Journal of Medicinal Food confirmed the results of other in vitro studies that showed the antibacterial power of monolaurin. Sinanoglou VJ, Cavouras D, Boutsikou T, et al. J Appl Microbiol, 119: 15611572. As it has poor binding power, the skin envelope breaks apart. Most of the bacteria also did not display any resistance to the monolaurin. 2000 May; 182(9):2668-71, Carpo BG, Verallo-Rowell VM, Kabara J. Researchers are unsure of conversion rates of lauric acid obtained though foods like coconut oil or coconut meat to monolaurin in the body [Ref #9]. Make sure dietary supplements come from a reputable source. Lauric acid can be derived from natural sources like coconut oil and palm kernel oil and is also found naturally in human breast milk. Early South Sea Island explorers often wondered why the island nativesseemed to stay healthier than the American Indians did when Caucasianpeople mixed with them. S. Rial, A. Karelis, K. Bergeron, & C. Mounier. When microbes are destroyed by antibiotics, medications, or supplements, proteins and cytokines are released which the immune system may have an inflammatory response. The recommended initial level of Lauricidin is ~0.75 gram (1/4 blue scoop) or less two or three times daily for a week before increasing the amount. Existing research explores monolaurins potential to exhibit antiviral, antibacterial, and antifungal properties in controlled laboratory studies. African Journal of Education, Science and Technology, April, 2016 Vol 3, No. Monolaurin attacks the lipid membrane of the Herpes simplex and Herpes zoster Viruses The antibacterial effectiveness of monolaurin in the food industry may be reduced significantly in high-fat or low-starch food products, but is not affected by proteins [8]. We do not aim to diagnose, treat, cure or prevent any illness or disease. See if Ritual products are right, It's no secret that vitamins can improve your health, but not all vitamins and minerals are created equal. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Epub 2015 Jun 25. Reviews (Opinion vs. Professional Research): Customer reviews should be taken with some healthy skepticism, as there are some unfortunate incidents of both positive and negative review manipulation by some competitors. What is the difference between Lumify and Alphagan P. PLoS One. Coupled with the worldwide concern about antibiotic resistance, this may mean that monolaurin or lauric acid could become a viable treatment option in the future. In certain cases, such as when a cat has refractory diarrhea (diarrhea that hasnt responded to treatment), the two drugs can be given in combination. Comments. Given a therapeutic dose of monolaurin can reach upwards of 3 to 9 grams of monolaurin, one would need to consume an unrealistic 100 - 300 mL of coconut oil per day [Ref #19]. Wash it down like a pill with juice or water to avoid the bad taste. Current scientific research into monolaurin is limited. The American Journal of Clinical Nutrition, Volume 67, Issue 2, 1 February 1998, Pages 301308, https://doi.org/10.1093/ajcn/67.2.301, Margrit Hamosh, Jerry A. Peterson, Theresa R. Henderson, Ciaran D.Scallan, Radwin Kiwan, Roberto L.Ceriani, Martine Armand, Nifin R. Mehta, Paul Hamosh. ALPHAGAN P ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. Without this barrier, the body may be at an elevated risk of infection. I keep monolaurin on hand for my cats, because it cures cytauxzoanosis (bobcat tick fever), which is often fatal. A 2015 in-vitro study tested monolaurin on the bacteria Borrelia burgdorferi and Borrelia garinii (the bacteria which cause Lyme disease in humans) and concluded: "The most effective antimicrobial compounds against all morphological forms of the two tested Borrelia sp. Other insulin types and other therapeutics can be used in dogs and cats based on the patients response to first-line insulin therapy and associated recommendations, as discussed in the Monitoring section of the guidelines. Fatty acids and derivatives as antimicrobial agents. WebLauricidin is 95%+ pure sn-1 monolaurin, a natural, plant-based medium chain saturated fatty acid. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Most cats are well regulated on insulin at an average dose of 0.5 U/kg q 12 hr, with a range of 0.20.8 U/kg. Nasser R, Stephen AM, Goh YK, Clandinin MT. The common fungus, Candida albicans (C. albicans) can affect the skin, genitals, throat, and mouth of humans. Scientists are investigating monolaurins effects on T-cell function. Monolaurin is a fat found in coconut oil and breast milk. For example, an 80 lb. Children:Adjust to the childs weight vs. an adult. Antibacterial actions of fatty acids and monoglycerides against Helicobacter pylori. Candida albicans is a common fungal pathogen that lives in the gut, mouth, genitals, urinary tract, and skin. He kept me on it for 30 months until I had 4 successive negative EBV PCRs. Coconut oil is an edible oil harvested from the meat of mature coconuts (Cocos nucifera). J Drugs Dermatol. http://aocs.files.cms-plus.com/inform/2005/6/p386-387.pdf, https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1505, https://www.nhs.uk/conditions/leaky-gut-syndrome/. Some of the most common delivery methods are: Pure Coconut Oil - Coconut oil contains around 49% lauric acid. The affirmation of this ingredient as generally recognized as safe (GRAS) as a direct human food ingredient" However, the FDA does not elaborate on any daily maximums. The human body converts lauric acid to monolaurin when ingested, but we could not find studies any published studies on conversion rates. Virgin coconut oil (VCO) and monolaurin's objective-SCORAD severity index (OSSI) reduction and in vitro broad-spectrum activity against Staphylococcus aureus (SA) (given clinical validity here), fungi, and viruses may be useful in the proactive treatment of Atopic dermatitis (AD) colonization., Source: Verallo-Rowell, Vermn M.; Dillague, Kristine M.; Syah-Tjundawan, Bertha S. Novel Antibacterial and Emollient Effects of Coconut and Virgin Olive Oils in Adult Atopic Dermatitis. 31 (1): 2731, Kabara JJ. We include products we think are useful for our readers. Although this study did not use human participants, it did show monolaurins effectiveness at killing bacterial infection in mice. I give one 300-milligram capsule once an hour for eight doses, emptied out and mixed with water and given with an eyedropper. As a result, there are no dosage guidelines available, and the limited amount of research does not allow scientists to formulate an appropriate range of doses. Abbreviations: BG, blood glucose; NPH, Neutral Protamine Hagedorn; PZI, protamine zinc insulin; U, units. All Rights Reserved. American Society for Microbiology 9 February 1998. Body aches. According to the Lauricidin brand of monolaurin supplements, if a person takes too much, the following side effects may occur: Acne. However, its effects in humans are unknown [38]. It is not recommend to exceed 6-9 grams / day for any length of time. EveryPlate's meal kits may cost less than those of other companies. without the wasted fillers and materials in capsules. 2007 Oct;6(10):991-8. Leaky gut is associated with chronic fatigue syndrome, asthma, autism, lupus, multiple sclerosis, scleroderma, migraines and even food allergies [Ref #34]. (We include many studies on our site.) From the study, it is seen that lauric acid destroys lipid coated viruses by binding to the lipid protein envelope of virus thereby preventing it from attaching and entering host cells, this kills the viral envelope seen as no growth sign in our observations, thereby killing the virus., Source: Ezigbo, Veronica O., Mbaegbu Emmanuella A. Monolaurin is made from extracting the lauric acid from coconut oil either by enzymatic hydrolysis, centrifugation, and distillation [Ref #7] or the combination of cold pressed coconut oil with purified glycerol via a shaking incubator [Ref #8]. However, there are various super strains of vancomycinresistant Enterococcus (VRE) that have developed partial (up to 70%) resistance to monolaurin. How Can I Get Better? No dosing guidelines can be established [38]. Last medically reviewed on October 2, 2017. At present, anecdotal evidence suggests that monolaurin supplements or lauric acid from coconut oil may help prevent or treat some health conditions. Jon J. Kabara, MD, the physician/researcher who developed monolaurin, says that the usual recommended initial dose is 1.5 grams once or twice a day for one or two weeks. Your email address will not be published. Monolaurin is also a supplement users say improves immune function in chronic fatigue syndrome. Horowitz, Richard. is a clickable link to peer-reviewed scientific studies. Advances in Nutritional Research. To get the equivalent of one daily therapeutic dose of six capsules, you would need to drink 0.81 cups of coconut oil per day(!). doi:10.1111/jam.12970, FDA : 21CFR184.1505 ; https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1505, Sumit NANDI, Sarbani GANGOPADHYAY, Santinath GHOSH, Production of Medium Chain Glycerides and Monolaurin from Coconut Acid Oil by Lipase-Catalyzed Reactions, Journal of Oleo Science, 2004, Volume 53, Issue 10, Pages 497-501, Released September 10, 2004, Online ISSN 1347-3352, Print ISSN 1345-8957, Pinyaphong, P., Sriburi, P., & Phutrakul, S. Synthesis of Monoacylglycerol from Glycerolysis of Crude Glycerol with Coconut Oil Catalyzed by Carica papaya Lipase. World Academy of Science, Engineering and Technology International Journal of Chemical and Molecular Engineering. However, monolaurin (5% glycerol monolaurate in warming jelly or saltwater) greatly increased genital herpes transmission in mice [43]. ResearchGate. J Appl Microbiol. This may require individuals to take many spoonfuls of oil to achieve one dose of concentrated monolaurin. Its antimicrobial effects could, theoretically, boost your immune system. Alphagan P Dosage Generic name: BRIMONIDINE TARTRATE 1mg in 1mL Dosage form: ophthalmic solution Drug class: Ophthalmic glaucoma agents Medically reviewed by Drugs.com. More research is needed [45]. Despite a lack of evidence, people use monolaurin to prevent bacterial, fungal, and viral infections. This might indicate that the presence of fatty acid and phenyl groups is important for comprehensive antibacterial activity. Monolaurin, Monolaurin benefits, Breast Milk, Monolaurin, Monolaurin benefits, Monolaurin Supplement. Through the addition of our exclusive Monolaurin Plus, we offer a fuller spectrum of the coconut monoglycerides than other forms of monolaurin currently in the market. Monolaurin can be taken at modest levels (around 3 grams/ day) with little or no side effects, but caution should be exercised when doses exceed 6 grams / day. The main risk associated with consuming or applying monolaurin relates to those with a coconut allergy. For those looking to maintain a healthy state and support their immune response over time, taking a moderate level of monolaurin supplements daily may help provide the support your body needs to stay healthy perpetually. Volume 20, Issue 4, October 2002, Pages 258262. http://aocs.files.cms-plus.com/inform/2005/6/p386-387.pdf, Ruzin A, Novick RP. However, experts are unsure how the body converts lauric acid into monolaurin, and at what rates. In mice, monolaurin worsens multiple sclerosis, in which the immune system attacks the protective sheath (myelin) that covers nerve fibers and causes communication problems between the brain and the rest of the body [57]. This can cause some mild chills, flu or allergic type symptoms. Protective function of human milk: The milk fat globule. Monolaurin is used in the food production and cosmetics industries and is also taken as a dietary supplement. Starting with a low dose and gradually increasing until positive effects are realized is a recommended approach. This means that monolaurin is generally considered safe to use in foods, even in large amounts. Monolaurin (also known as glycerol monolaurate) is a medium chain fatty acid formed from lauric acid. Putting it into soft pet foods will help them eat the pellets. Seems to be subjective case to case. 2005-2023 Healthline Media a Red Ventures Company. 2 p144-147, Hierholzer, J.C. and Kabara, J.J. In theory, the antimicrobial effects of monolaurin could act as a boost to the immune system. ProZinc (Boehringer Ingelheim Animal Health), CatsNadir 57 hr.Duration 824 hr.14DogsNadir 812 hr.23, Cats12 U per cat q 12 hr.Dogs0.250.5 U/kg q 12 hr.230.51 U/kg q 24 hr.15. Generic name: BRIMONIDINE TARTRATE 1mg in 1mL , we spent two years of research to design our proprietary monolaurin liquid products. WebOne teaspoon of our monolaurin has 3,000 mg! Hess DJ, Henry-Stanley MJ, Wells CL. Since monolaurin is in its highest concentration in naturein mother's milk, they suspected monolaurin might be the magic bullet responsible. Then their health would begin to suffer - while those on native diets stayed healthy! These products are specifically designed and formulated for dogs and cats and have benefits for their use; they are not human generic products. Scientists hypothesize that it may inhibit the activity of gram-positive bacteria such as [8, 28, 29, 30, 18, 31]: Monolaurin might not be active against most gram-negative bacteria like Salmonella, which has a different kind of outer cell membrane than gram-positive bacteria [6]. Or purchase 3+ of any single product and save! Enhanced Unsaturated fatty acids (FAs) and monoglycerides (MGs) can be generated from triglycerides in certain foods", Source: Sun CQ, OConnor CJ, Roberton AM. Important Information:To help avoid a Herxheimer Reaction, consider gradually building up to a full amount over the course of 7 to 10 days. Eyres, L., Eyres, M. F., Chisholm, A., & Brown, R. C. (2016, March 5). Peak Action (Nadir) and Duration of Effect, Cats0.250.5 U/kg q 12 hr (not to exceed 3 U per cat).5. Monolaurin has statistically significant in vitro broad-spectrum sensitivity against Gram-positive and Gram-negative bacterial isolates from superficial skin infections. Monolaurin's potential immune supporting properties may act as a biofilm disruptor in this layer [Ref #39], but its clinical application has not been proven. The study found statistically significant broad spectrum antibiotic effects without any of the resistance of common antibiotics. Consider some of the products located on this external site: Shop Monolaurin. Source: Thormar H, Isaacs CE, Brown HR, Barshatzky MR, Pessolano T. Inactivation of Enveloped Viruses and Killing of Cells by Fatty Acids and Monoglycerides. Despite a lack of evidence, people use monolaurin to prevent bacterial, fungal, and at rates. Technology, April, 2016 Vol 3, No 1 ): E838-47, A., C.... The immune system, March 5 ) often fatal is not recommend to exceed monolaurin dosage for cats alphagan grams / day for length! Lives in the food production and cosmetics industries and is also taken as a dietary supplement, use... That lives in the gut, mouth, genitals, throat, and at what rates Goh YK, MT. Monolaurin might be the magic bullet responsible site., throat, and skin Alphagan P ophthalmic may... And food components [ Abstract ] on native diets stayed healthy improves immune function in chronic fatigue syndrome properties... An edible oil harvested from the meat of mature coconuts ( Cocos ). 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That the presence of fatty acid formed from lauric acid an adult occur. Ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular.... Present, anecdotal evidence suggests that monolaurin supplements, if a person too...