Banfield also pushed it on us saying that they no longer sold the other we used that I can't think of right now because I am so upset. After doing some research, we rejected that idea, instead we gave him a charcoal detox, he had recovered the next day. At first B seemed fine. Couple of days ago, I took my other doxie (Maddie) into my vet, for shots, he did the heart worm test and recommended Simparica. Im really trying to understand the science behind what is happening to my puppy and the vet, neurologist, drug company have been little help. My older dog had his enzyme levels checked after taking 5 months of simparica and they were elevated 26x the nomal level. I made some chicken and rice. Could use of Simparica be related to increased prevalence of mast cell tumors in dogs? He also had a blood test done and all was normal. I'll tell you what I can meningitis is the swelling of tissue surrounding the brain and spinal column and can be cause by either bacteria or a virus. (145 Reviews) $15.50 - $31.09. I just hope he has a turn around . Not to worry you, and I hope yours is different outcome! I would absolutely rather be safe than sorry.. no more simparica trio for that guy. I am currently in the same situation and we are at day 16 after giving simparica. I gave this to my #3. The vet came and picked her up and cut her opened and said and told me she could anything wrong with her so it was either she was poisoned or it was a neurological disorder. Any believers out there please say a prayer for our pup as I will for the people on this thread. Those with Diarrhea symptom, did it look like mucus in their pets stool? Gave our 23 month old Black Lab. Then they come back! They want $5k to do a spinal tap and MRI. How long did these symptoms last? I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market. Does your do still have a cough? The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. It is really important to call if your pet is experiencing any symptoms from these medications. Reading all these similar cases cant figure out how the hell this crap is still being prescribed. Conclusion On August 17th, we had to rush him to the ER because he was not moving. Dogs Naturally Market is a good source to check out. She had a beautiful coat of fur. He will be laying then start shaking all over..Has tremors every 5 minutes for 2 hours now. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. This is because it doesn't kill adult heartworms. Has anyone had a dermatitis issue as a result of Simparica? We have had to put a donut around his neck to keep him from causing more open sores and possibly infection. Seizures are going on two hours.. I am so mad at myself and so upset that I am the one that has made him sick. Some pets fare better with topical solutions instead of chewables. He has been on simparica since he was old enough to take it. I am so mad at the vet and think we should file suit against this company. I gave my 5 lb maltipoo a new flea treatment called Simparica and two weeks later she started having seizures. What number do we call for FDA? So sorry to hear, and good for you in recognizing the problem! I fell like hes dying right before my hands. It is a horrible feeling that your healthy, funny, lively dog can become disabled overnight just because you trusted a medication. my vet recommended this for both my yorkies. On the first day he woke up and peed in my bedroom floor. This drug has caused our dog to loose his footing and not eat. I even told them about the Simparica which they dont respond to. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. He has no appetite and very little drinking either so hes not using the bathroom much. Any tips on how to flush it from her system ? I gave this to my 4 month old puppy and was not told of the neurological side effects. I feel horrible for listening to the vet without researching this on my own. What Are The Side Effects Of Simparica Trio For Dogs? I PRAY that our baby is okay with this second dose. Those incidents are still under investigation because the numbers of report are extremely low. My dog has been vomiting with diarrhea plus he has bumps all over his body from one dose of simparica trio. During this period coincidentally I have noticed a change in his behaviour. Your vet should be able to answer any questions related to side effects, precautions, or special care for your dog. If there are enough reports they may have to pull it off the market until further safety tests can be done. Its now about May 16th 2021. About 11 months ago our vet recommended Simparica Trio. He came over to me and laid his head on my lap (he is a big baby), but he seems "off" like not his usual self. This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. I am so angry. I took my dog to the vet today and she received fluids and gabapentin. I gave him this medication last Thursday. Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. In addition to ease of use, it has been tested in many field trials and proven to work effectively against fleas, ticks, and worms in dogs. It could be a coincidence but seems too coincidental. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. 8 months of prednisone and around the clock nursing care at home saved her life. I just found these comments and I am feeling terrible. Then giving more drugs for itching. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hoursincluding the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. We are closely monitoring him. Never happened before. I argued with the vet that this is poison and she said why would I give your dog poison? Started downhill health issues with initial dose. I know it's still in her system because I am still finding dead ticks that I miss because they are the size of a sesame seed. So I started searching and came across this blog and my heart just sank. He wouldnt survive surgical attempt to go in and try to figure out what was going on. I will do anything to stop this from hurting or killing anyone else's baby. Supposedly it is MDR1 friendly but side effects include ataxia which is what my girl got. Do you have a homeopathic vet in your area? Some years back my husband gave vet approved & sold oral flea/tic medication to each of our 2 Standard Poodles. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. Good bless you all. I thought maybe my dog had a bladder infection or got into something that upset her gut. He had been on it for 4-5 months . Simparica Trio has been extensively tested on various breeds and on dogs of different ages. He eats and drinks fine but looks like we havent fed him in days. Mine is. She's been fine since. Final Thoughts on Trifexis vs Simparica. All went well until this morning. Will NEVER give this to my dog again. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). Today started diarrhea & he has gone 5 times so far while not eating much. I notified my vet and Zoetis, the company that makes this drug. He seems sometimes anxious and is sensitive to noise outside. Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. She gave her a shot to keep her from throwing up and took her x-rays and told me to come back the next day if she wasn't better. This went on for 4 hours. But anyways - the other night , his feet collapsed from under him & he fainted . I was reading that this drug enters the bloodstream quickly after giving it, and these symptoms and all the other reports have convinced me that I'm done using this on my pup. I sure hope we don't have ongoing problems. This medication is generally well tolerated in most pets. Anyway, he prescribed him pain relief for 7 days. Although he didnt continue throwing up and was fine otherwise, he was still outside 12 hours later eating grass. Two quick questionsDo the dogs eventually return to normal? I wish every one the best. He is also running a fever so is not out of the woods. She wanted me to monitor him carefully and wait to see how he did on his next dose of Simparica before continuing to prescribe it. She gets anxious and paces if I run into the grocery store even though my husband sits in the car with her. He was admitted and ultimately spend 5 days and 4 nights there having additional blood work, x-rays, endoscopy, ultrasound. He was a Shih Tzu. I don't give him much treat eather. How is your dog doing at this time? I had to put him on ani seizures meds due to some being clusters so unable to tell if he is getting better or the meds are just preventing it. He isnt losing weight but really looks horrible. You can switch to another oral flea med but nothing for ticks, those are all versions of the same med. She has been taking Trifexis for years with no problem. After reading all your entries, i'm thrilled i chose to take her off of it. The company that makes it said they didnt change the flavor, but I live in a high tick area, so switched to Simparica Trio. My Irish setter is weak on her left side, left side of her face is drooping and she now carries her head with a tilt to the left. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. She does have history of seizures. Overly anxious. Last year I gave them this but didn't notice any issues. We think that the drug is the cause of the seizures . I gave this poison to my almost 3 year old Yorkie she is dying as I right this. Im switching back to the old stuff. She keeps running through the house as though looking for something. After realizing that the only thing that we did differently was to give him his first dose of Simperica, my wife began research and came across this conversation. Losing my Dolly devastated me and I wanted to warn others about Simparica but I got sick. Our 6 year old, 66# Treeing Walker Coon Hound baby has been taking Simparica for about two years. (On Monday, she fell down several times in an hour. Ive spent over $3,000 on vet bills for at least four visits to the ER and follow up lab work including X-rays. Vet thinks it may be Addision disease and wants to test for it. Revolution has been around decades with less incidents of animal reactions. Idk what to do. We rescued another dog. I gave my dog his first dose today and 6 hours later he was throwing up and became frantic to get outside to eat grass. In our case the damage was permanent. Do not give extra or double doses. My last one lived to almost 15yrs old and I truly believe it was because I had him on Springtime Garlic tabs. Dr said either Simparica (best case scenario), GOLPP or brain tumor. I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? While she has not had seizures, trembling, or spasms, sometimes she just squeals and jumps up for no obvious reason. This time I am seeing a little blood or tissue in her stool. It kills heartworm larvae by causing paralysis that leads to the death of the parasite. He had his second dose on 3rd July. . No problem eating. I will not give it to my puppy again, but what is a safer med. We got to the Animal Hospital . If it has been a long period of time since the last dose was given, you may see fleas temporarily during the missed time. Argh. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. The cardiologist found no heart condition that would cause this. Today is Friday. He walked outside peed then tried to come back in the house but his legs gave out . The vet suggested this medication for my 9+ yr old English Bulldog. He seems to be out of sorts, staring into space, getting freaked out when he can't see me (I thought he was losing his eyesight). Was hospitalized for 2 1/2 days. He first started with seizures and losing weight in June after giving him Simparica. Thankfully there have been no other side effects. No seizures yet thank goodness, but he is drinking a ton of water. Read package insert - yes was tested on female dogs who were bred. Over the past month she has stumbled a few times when on walks. She's been given this dosage for over a year. 5 hours after the dose she's home resting. It is now day 37 since her last Simparica and I will not ever give her another one. One common alternative is to give Heartgard for heartworms and intestinal parasites along with Bravecto to prevent fleas and ticks, but there are other choices out there. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. I will not in good conscience continue to give my three previously healthy dogs anymore Simparica Trio as it causing Gand Mal seizures in my older dog and nausea , vomiting and severe thirst and dehydration. I wanted to investigate a bit before dosing him. Was checking out before using . Them I took him to a vet for check up and to my horror, he has fleas and a tick. 3 days later, one of the dogs had severe vomiting for a day, then turned into severe golden diaherria going on a week now! 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