2005-2023Everyday Health, Inc., a Ziff Davis company. Anyone with very low AMH do the estrogen priming and have a good response? I think you both are at Cornell (were) with this estrogen priming protocol will you try again with them, and request not to do estrogen priming? you are not supposed to TTC on the cycle you will be doing the EPP because of the ganirelix. He did say there are some studies that DHEA and CoQ10 could help, but the, Hi all. Baby boy born May 2, 2013, Full details are now in my profile "About Me" page. i had success with DE. Best of luck to you. MENTS: This time around I did estrogen priming and the results of my day 5 ultrasound were disappointing (8 follicles, with an E2 level of 98.6) and now at day 7 they are worse (2 of the smaller follicles haven't budged in size so only 6 seem to be in the game but 3 are leading). EPP is an aggressive form of an IVF Antagonist Protocol. I cannot say if it will be a success yet, as I am currently doing the EPP protocol. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. EPP results: 17 retrieved, 13 mature, 8 fertilized with PICSI, 2 hatching blasts on day 6 have been biopised. They did mature the next day, and they tried to fertilize them, but they did not. FET October 6, 2010 - this is it Thank you for subscribing to our newsletter! Below is an oversimplified way to visualize this. But I also realize I'm not a dr and should probably listen to their advice! Lupton trigger. Please whitelist our site to get all the best deals and offers from our partners. Any success stories for low responders of Estrogen Priming cycle? day 1 of cycle/protocol: (day 2 of menses): cetrotide 0.125 mg subcutaneously 4 estradot patches (estradot patches to be stopped when lead follicle was greater or equal to 1.5 cm) days 2 and 3 of cycle: 600 iu gonal f 0.125 mg cetrotide days 4 - 6 of cycle: 525 iu gonal f 0.125 mg cetrotide days 7 - 11 of cycle: 225 iu gonal f 0.125 cetrotide Ovarian Stimulation Baseline Ultrasound Estrogen Priming protocol does not have birth control pills. 2 expanded blasts on Day 6 were not biospied. Johns Hopkins School of Medicine, Medical Director, REI 225 Gonal f and 225 menopur for 4 days then menopur only (450) for the rest of my stims. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. Estrogen priming is pretty standard for over 40. Many customers have had positive experiences ordering from them, and their customer service has been praised for keeping buyers updated on order status. I just had my first IVF and it was unsuccesful. I went to a UK FSH friendly (thank you joy for the recommendation) clinic for a consultation. A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. In the case of the fresh transfers, you can clearly see a similar effect to what investigators found above: success rates drop with more drug. Though I had 4 or 5 follicles to begin with, only ended . You are posting as a Guest without being logged in. Now this is a guesstimated number. As a result, most fertility doctors shoot to retrieve 15 to 20 mature eggs per cycle. You still may have a BFP, so let's wait to see before we say it didn't work!! Our mission is to be a trusted partner in helping you understand your reproductive health and to support and empower the choices you make along the way. Has anyone else had this, Hi peeps. That sounds nuts to me, but my doctor said that it is normal. Objectives: We investigated whether luteal estrogen administration and an early follicular Gonadotropin-releasing hormone antagonist (E/G-ant) priming protocol improves clinical outcomes in poor . E2 level 96.4. This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization Waft really helped was upping gonal f and removing menopur. My next cycle will also be EPP. Im on this for 21 days starting on cycle day 1. Did one cycle of IVf with 450 of gonal F and then cetrotide and ovidrel. I know this is old but was your period seriously delayed after estradiol patch? Long time reader, first time poster. (Not so) Short summary - DH and I have been ttc since May 2015, two early m/c. However other had mature egg and we did Icsi by it didn't grow from there. During cycle 1 you use OPKs to track your LH surge and ovulation. Lets start with how much gonadotropin to take. No BCP - started my period, did cycle day 2 testing FSH was good (I had high a FSH of 15 so EPP helped that) then started meds. Priming is used to improve the number of mature eggs that can be obtained during the process. To get FSH, patients take Gonal-F or Follistim (many consider them to be interchangeable) and to get FSH-plus-LH most women take Menopur (pretty much the only product on the market). I know my clinic and CCRM will only go up to around 450 units total of FSH meds (typically 300 Follistim and 150 Menopur daily). Spandorfer said it would not suppress me to much not sure about this, need to speak with him further. FertilitySmarts is a part of Janalta Interactive. Hottest Topics -- Last 30 Days We did an antagonist protocol with gonal f, menopur and ganirelix last time and only ended up with 2 embryos on day 3 if that helps. Below you can see that when investigators gave poor responders 450 IUs or 150 IUs per day, the groups had nearly identical success rates. When do you start your next cycle? I need to know if anyone has had a similar experience, but later got pregnant and where did you go. The dose of gonadotropin matters because, generally speaking, if too little is prescribed, too few eggs are retrieved, and IVF success rates go down. Dr Sher says "oestrogen priming of FSH receptors has been reported to slow premature follicular development and to promote granulosa cell FSH receptor induction". Beta 2093 I am just hoping between the estrace and progesterone my period holds off until next Thursday! Estrogen Priming is completely different, so therefore without birth control pill.I would ask your doctor, but I guess you just do nothing while preparing for the cycle. Find advice, support and good company (and some stuff just for fun). I was on the highest dosage of Gonal with that cycle. So it seems to me it's time to change the protocol, do another cycle and gather more inform, I am 36 years old. They want to try the Estrogen Priming protocol with estrace and prometrium for almost 4 weeks before the stim cycle. We use data about you for a number of purposes explained in the links below. This time she is switching me to EPP w/ 100 Follistim/150 Menopur. I am interested in hearing from women who have never tried to get pregnant and therefore do not have any specific infertility issue per se, other than age. Is a micro-dose lupron protocol considered a low-dose protocol? This drug prompts the brain to release LH, the signal for ovulation, and is effective in helping to avoid OHSS. Went to retrieval anyway, did ICSI, but it didn't fertilize. my RE is going back to the drawing board for my final IVF. I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. These include estrogen, FSH, LH and inhibin amongst many others. BFP oct 16th!!! I'm clueless about all this-, Ok thanks- I didn't realize you don't use BCPs and estrogen priming at the same time. Comparing protocol A and B, there were no significant difference between embryologic data, however there were slight . I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. It's possible to pay with credit card or Western Union, but PayPal isn't an option. Dont know what. By clicking sign up, you agree to receive emails from FertilitySmarts and agree to our Terms of Use & Privacy Policy. As you can see below, success rates dropped. Ugh, that made me feel like I was hit by a truck. One thing to keep in mind is that every cycle, there is a new cohort of follicles availble to be stimulated, meaning that during different months the same protocol may work more successfully than others simply due to the natural variation in available follicles. I know you ladies all have your own stuff going on and I feel terrible asking but I dont know who else to askBarb, penny, joy, anyone else, Ive read that an estrogen priming protocol is good for DOR women, do you know if this is true? poor responders or women with PCOS). 1997-2023 BabyCenter, LLC, a Ziff Davis company. However, for poor responders many doctors worry such a long duration of suppression can hurt outcomes. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Good luck! I'm 40, doing IVFdue to age and a mc at 10 weeks due to Trisomy18. I starts on day 1 of my cycle for 25-26 days of estrace.. Not sure why.. undefined will no longer be visible to you including posts, replies, and photos. Candice maybe11 129 Dec 08, 2009 #3 Hi, Most of the costs are for the ER visit, tests, and lab work from my night in the hospital and the weeks following. We strive to provide you with a high quality community experience. I am about to embark on my IVF#6 cycle (1st time at CCRM)- I've always done OCP/BCP before my IVF stim cycle(antagonist) and have produced between 15-19 eggs each time. After being on BCPs for so long, it took a long time for my period to come back (it's been 5 years though now), but my cycle has still never been the same so I'm wary of BCPs. That data comes from an analysis of over 700,000 IVF cycles run by well-respected investigators at Stanford. This is called multi-follicular development and its a pivotal step in a successful IVF. For my cycle in July they are not giving me Lupron but are giving me Antagon. I am on my 4th now. Ramped up to cycle on BCP for two weeks and Lupron 10 units 2x/day on stims. Below is data collected on over 3,000 cycles for each protocol approach in the Netherlands. Yes, I did antagonist for IVF 1, 2 and 3. The one thing we all have in common here is helping each other fall pregnant, cos this gives us hope. By: Kelly Park I asked my local RE about it, but she wasn't familiar enough with it to try. Are you wanting to learn more about the IVF process? Ivf doctor recommendation in nyc or bklyn, Low Ovarian Reserve and Poor Responder to IVF, Ladies 45 and older TTC - *infertility due to age only*. me: 37 This is standard practice when ordering from Ukraine, according to customers wh. Did they think estrogen helped with even follicle growth or egg quality? That could be why they are decreasing your Follistim too. Surprise spontaneous just 7 months postpartum while still breastfeeding!!! Froze 3. In the next section well walk you through the mechanics of each protocol. Estrogen priming is typically done for about seven days before the start of controlled ovarian stimulation (the IVF cycle). However, that information will still be included in details such as numbers of replies. :) Keep us posted on your progress! Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are used to stimulate the ovaries to recruit and develop more than one follicle. Another set of investigators looked at a variation of the same question. The combination of drugs and their dosing is known as a protocol and while it may seem like there are a dizzying number of protocols, the reality is there are only a few core options. Estrogen priming has worked both times for me. We're not even 100% sure we are staying with my current clinic but I wanted to research ahead of time either way. There are two downsides to this protocols: The long duration of injections (they start the previous cycle) and. First round I had few follicles 10 and scattered growth after taking bcp before cycles for about 13 days; Tried epp round after that, and had more synchronized growth with same number of follicles. Any 43+ Have Successful IVF with Own Egg? This website uses cookies for functionality, analytics and advertising purposes as described in our, http://www.fertstert.org/article/S0015-0282. What To Do When PGT-A & Grading Results Conflict? I did estrogen and testosterone priming on my second ivf because I was oversuppressed during my first cycle. Thanks! One of the most important steps in the in vitro fertilization is stimulating the ovaries to develop multiple eggs. xx, Oww Hun, please dont worry about me, look after yourself, here if you need a listening ear xxx. AMH 28. Natural cycle is no meds to stim so u get 1 egg at best. I did EPP, using a climara patch every other day starting day 8 after ovulation until came. 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