Our reported case adds to the other findings regarding the association of PR with SARS-CoV-2 infection, in the context of the pandemic, suggesting the need to test patients with PR skin lesions for SARS-CoV-2 infection. MeSH The patches may itch. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Epub 2020 Jun 5. PMC Children often get infected when someone sneezes or kisses them. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Epub 2021 May 10. While home remedies are safe for most people, its a good idea to check with your healthcare provider before trying some of the following options. Coronavirus disease 2019 and pityriasis rosea: A review of the immunological connection. The https:// ensures that you are connecting to the The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. J Eur Acad Dermatol Venereol 2020;34:e2123. Hum Vaccin Immunother. Cutaneous manifestation has been reported in 0.2% of patients infected by COVID-19 in China, and 18 out of 88 patients from Italy. While annoyingly itchy, the rash does not cause any serious long-term side effects and is not contagious, unlike the diseases these vaccines protect against. FOIA You may initially develop a fever, headache or upper respiratory infection. Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review. It looked like one, and it certainly itched like one but then more came. doi: 10.1111/bjd.20143. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. J Am Acad Dermatol. Chanprapaph K, Pomsoong C, Tankunakorn J, Eden C, Suchonwanit P, Rutnin S. Comparative analyses of clinical features, histopathology, and CD123 immunohistochemistry of oral lupus erythematosus, lichen planus, and other lichenoid lesions. and transmitted securely. The papulovesicular and pityriasis rosea . "Sometimes it can spread to what we called the proximal extremities, meaning the parts that are closer to the trunk, so the shoulders, upper arms, [and] the thighs," she says. Most people with the rash are 10 to 35 years of age. Proc (Bayl Univ Med Cent). Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine Pityriasis rosea (PR) is an acute papulosquamous cutaneous disorder that classically presents with a herald patch rapidly followed by a widespread rash along skin cleavage lines. Busto-Leis JM, Servera-Negre G, Mayor-Ibarguren A, Sendagorta-Cuds E, Feito-Rodrguez M, Nuo-Gonzlez A, et al. In: Papadakis MA, McPhee SJ, Bernstein J., eds. Pityriasis rosea, COVID-19 and vaccination: new keys to understand an old acquaintance. It could be pityriasis rosea here's how to treat it. Suchonwanit P, Rojhirunsakool S, Khunkhet S. A randomized, investigator-blinded, controlled, split-scalp study of the efficacy and safety of a 1550-nm fractional erbium-glass laser, used in combination with topical 5% minoxidil versus 5% minoxidil alone, for the treatment of androgenetic alopecia. A few days later, the cluster came: Ten little dots arranged themselves in a perfect alien-like crop circle on my upper back, and they itched so much that I scratched them raw. Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 [Epub ahead of print]. This rash is thought to be caused by a virus. Alamri A, Alghamdi Y, Alamri SJ, Althaqafi MK, AlQurashi W, Bader BA, Mohanna AT, Almahdi B. Cureus. (2021) 85:4655. "In studies, between 2 and 3 percent of people develop the disease again. From grooming sets to self-care gadgets, we've got them covered. Other plausible theories include molecular mimicry with viral epitopes and type IV delayed hypersensitivity reaction (12). COVID-19 Skin Manifestation Heterogeneity - MedicineNet J Am Acad Dermatol. The mechanisms behind these COVID-19-related symptoms remain unclear. Drago F, Ciccarese G, Javor S, Parodi A. Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. doi: 10.1159/000517971. Before See this image and copyright information in PMC. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. In approximately 50% of people with pityriasis rosea, the patches itch. Some rare cases can take up to three months. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. (2015) 2015:253154. doi: 10.1155/2015/253154, 14. I also had to stop working out and hiking for about a week, as Alexiades is right excessive perspiration worsened the itch. The most commonly inoculated vaccines include those against smallpox, followed by tuberculosis, poliomyelitis, influenza, and human papillomavirus virus (12, 13). Published by Wolters Kluwer Health, Inc. Leerunyakul K, Pakornphadungsit K, Suchonwanit P. Front Med (Lausanne). sharing sensitive information, make sure youre on a federal In: Jameson J, Fauci AS, Kasper DL, et al., eds. Disclaimer. Treatment with topical 0.1% triamcinolone acetonide twice daily showed partial response after seven days. Pearls and pitfalls: Adverse cutaneous reactions after COVID-19 vaccination. See this image and copyright information in PMC. "It looks very different.". No one knows what causes pityriasis rosea, though healthcare experts think a virus might be responsible. Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report. doi: 10.1111/dth.13730. official website and that any information you provide is encrypted World J Clin Cases. 2022 Aug;87(2):295. doi: 10.1016/j.jaad.2022.06.036. One case of pityriasis rosea is reported in a patient infected with COVID-19, and the most commonly reported features are exanthomatous rash, urticaria, chickenpox like vesicles, petechiae, and acute hemorrhagic edema of infancy. Clinical aspect of the lesions after 7days of treatment. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). In addition to a corticosteroid cream, New York City-based dermatologist Macrene Alexiades recommends keeping showers short and lukewarm, as "water, sweat, and soap reportedly irritate and inflame the lesions. Bathe or shower in lukewarm water. ", Though there's no single-known cause, King says, "pityriasis rosea is associated with reactivation of herpesviruses 6 and 7 [HHV-6 and HHV-7, respectively], which cause the primary rash, roseola, in infants. Unauthorized use of these marks is strictly prohibited. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. (2006) 12:1. doi: 10.5070/D380D8301D, 11. In addition to COVID-19 vaccination, she was currently taking medications (i.e., levetiracetam and thyroxin) for glioblastoma, and the two drugs had been prescribed for approximately nine months. If you have pityriasis rosea, you dont have to avoid any foods or drinks. A virus may cause pityriasis rosea, but experts aren't sure. Rybak-d'Obyrn J, Placek W, Owczarczyk-Saczonek A, Derkaczew M, Joniec E, Hofman R, Stompr M. Clin Cosmet Investig Dermatol. Fortunately, PR-like eruption is responsive to topical corticosteroids without any systemic adverse effects. Generalized Papulovesicular Eruption as a Side Effect of the Pfizer-BioNTech COVID-19 Vaccine. PS conceptualized the case report and revised the manuscript. Pityriasis rosea, COVID19 and vaccination: new keys to understand an eCollection 2022. Accessibility How long will it take my body to clear the rash? 2021 Aug;35(8):e491-e493. Six cases of pityriasis rosea following SARS-CoV-2 vaccination with BNT162b2. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. Cureus. doi: 10.1111/dth.13878, 10. JAAD Case Rep. 2021;7:9394. government site. 2022 Mar 15;10(3):624. doi: 10.3390/microorganisms10030624. Human herpesvirus-6, -7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. The site is secure. Diagnoses: 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. The .gov means its official. Unable to load your collection due to an error, Unable to load your delegates due to an error. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753512/), Visitation, mask requirements and COVID-19 information, sexually transmitted disease or infection. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. Epub 2021 Jun 10. PR is a common self-limited papulosquamous eruption typically presenting with a large solitary pink-colored patch or plaque (i.e., herald patch), followed by secondary eruptions of smaller erythematous patches or plaques with associated peripheral collarette scaling distributed along the cleavage lines of the trunk, forming a Christmas tree pattern (5). Pityriasis Rosea Induced by COVID-19 Vaccination - PubMed official website and that any information you provide is encrypted Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. At first, I thought it could be a fungal infection like ringworm, a common misdiagnosis, says Hartman, but my dermatologist ruled that out when I mentioned the additional spots erupting on my back via our video chat. The symptoms of pityriasis rosea usually develop in stages: Pityriasis rosea doesnt hurt. Appointments 216.444.5725 Appointments & Locations Request an Appointment Moreover, while dermoscopy may facilitate the diagnosis of PR, its utility for atypical PR or PR-like lesions is still limited. Anyone can get pityriasis rosea. 2021 Sep;35 (9):e546-e548. (2020) 33:e13878. Polack FP, Thomas SJ, Kitchin N, et al. Pityriasis Rosea. Epub 2022 Jan 5. 2022 Mar 9;35(3):342-343. doi: 10.1080/08998280.2022.2044742. A 3-cm oval plaque with peripheral scale, larger, MeSH Pityriasis rosea after Moderna mRNA-1273 vaccine: A case series and transmitted securely. Due to the temporal relationship between vaccination and onset of rash, COVID-19 vaccination was the most likely etiology. and transmitted securely. Ad Choices. Bookshelf Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. Careers. Bookshelf All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. . The appearance of pityriasis rosea following the first injection of the AstraZeneca vector vaccine suggests a causal connection. NCI CPTC Antibody Characterization Program. You also wont have permanent scarring or other damage to your skin. (2016) 55:e33843. See this image and copyright information in PMC. However, the studies dont conclusively prove that COVID-19 causes pityriasis rosea. Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. Vaccination is one of the cornerstones in the efforts towards ending the coronavirus disease 2019 (COVID-19) pandemic. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same vaccine. doi: 10.1111/ajd.13504. 2022 Aug;20(8):1123-1124. doi: 10.1111/ddg.14784. J Eur Acad Dermatol Venereol. Br J Dermatol. The patient developed papulovesicular lesions in the crease lines of the trunk and extremities, four days after inoculation with a recombinant coronavirus vaccine (Covishield, India). However, several adverse effects of COVID-19 vaccination have been identified. Nevertheless, the incidence of skin reactions after mRNA vaccinations was low. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same . Considering the actual epidemiological context, we performed a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay from nasal and pharyngeal swabs for coronavirus disease 2019 (COVID-19) to investigate the PR etiology. There isnt a cure, but it isnt contagious. It was described as "clinically reminiscent" of pityriasis rosea by the authors, from the divisions of dermatology and venereology, pathology, intensive care, and the virology laboratory, of the Hpital Cochin, Paris. eCollection 2022. COVID-19-associated pityriasis rosea in children: Case report and literature review. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Epub 2022 Feb 9. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. MeSH Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A An official website of the United States government. Would you like email updates of new search results? Dermatology. In conclusion, we have described the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. The https:// ensures that you are connecting to the This site needs JavaScript to work properly. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. HHS Vulnerability Disclosure, Help I put on some hydrocortisone and went to sleep, then woke up with another mark on my side, a couple inches below my armpit. -. In my experience, patients with darker skin are more likely to present with atypical forms of the disorder. 2021;35(8):e489e491. Bethesda, MD 20894, Web Policies Additionally, differences in incidence of this reaction after Pfizer and Moderna vaccination may suggest a differing host immune response incited by these vaccines which warrants further investigation. PMC Rationale: FOIA Although the exact pathophysiologic mechanisms of PR after vaccination remain unclear, immune responses to COVID-19 vaccines and disruption of T-cell mediated control of latent infections were implicated (12, 1518). Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. The https:// ensures that you are connecting to the Bethesda, MD 20894, Web Policies Clipboard, Search History, and several other advanced features are temporarily unavailable. Atypical pityriasis rosea associated with mRNA COVID19 vaccine "Like a lot of things in dermatology, unfortunately, we're not always sure what causes these rashes," says Lam. Due to the rising incidence of coronavirus disease 2019 (COVID-19) worldwide, mass vaccination has been the cornerstone in preventing viral spread and decreasing morbidity and mortality. Characterization of the inflammatory cell infiltrate in herald patches and fully developed eruptions of pityriasis rosea. COVID-19: Cutaneous manifestations and issues related to - UpToDate PMC The authors suggest more research is necessary. In: Knoop KJ, Stack LB, Storrow AB, et al., eds. Your skin may develop discolored patches (lesions) that look like scales or dry, crinkly paper. (No.) Now watch a pro surfer's entire daily routine: Follow Allure onInstagram andTwitter, orsubscribe to our newsletter to stay up to date on all things beauty. Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. (2021). Treatment was initiated with systemic corticosteroid therapy - hydrocortisone hemisuccinate 200 mg/day for 7 days, and loratadine 10 mg 2 times a day. NCI CPTC Antibody Characterization Program, Ritchie H., Mathieu E., Rodes-Guirao L., et al. Hardin J. Pityriasis Rosea. An official website of the United States government. "It's usually not from head to toe that's more atypical but there are some people that get it more in the groin area or in the armpit rather than on the trunk predominantly, which is just a variant.". Clinical manifestations and histopathologic findings of reported patients with pityriasis-rosea like eruptions following COVID-19 vaccination. Pityriasis rosea-like eruption revealing COVID-19. A virus may cause pityriasis rosea, but experts arent sure. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical and pathologic spectrum of mucocutaneous reactions Lessons: JAAD Int. If you develop pityriasis rosea, you may experience the following in this order: Feel ill for 1 or 2 days. Additional evidence that pityriasis rosea is associated with reactivation of human herpesvirus-6 and -7. Clin Exp Dermatol 2010;35:3004. Epub 2022 Jan 31. 2022 Aug 11;9(8):43. doi: 10.3390/medicines9080043. Epub 2022 Jun 21. (Unfortunately, I scratched my rash until it bled, so my hyperpigmentation may linger.). Studies show that the development of pityriasis rosea during pregnancy may cause birth complications, including miscarriage and poor muscle tone and development once the baby is born (neonatal hypotonia). 8600 Rockville Pike Clin Dermatol. Influenza viruses and vaccines have triggered pityriasis rosea in some cases.". Why rashes that follow COVID vaccines could be a 'good thing' We present a case of a pityriasis rosea-like rash occurring after Pfizer COVID-19 vaccination and review cases of pityriasis rosea (PR)/PR-like eruption (PR-LE) after mRNA COVID-19 vaccine published in the medical literature. Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk within days or weeks, says dermatologist Corey L. Hartman, founder of Skin Wellness Dermatology in Birmingham, Alabama. 2021 Nov 2;17(11):4097-4098. doi: 10.1080/21645515.2021.1963173. -, Neoh CY, Tan AW, Mohamed K, et al. Treatment may include various topical and oral drugs. 2020 Jul;33(4):e13730. doi: 10.1111/dth.13650, 7. The Covid Symptom Study. The site is secure. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. 2021 Nov;35(11):e721-e722. Various mild and benign cutaneous manifestations of the different forms of the COVID-19 vaccine have been documented. Our experience with 80 cases of SARS-CoV-2-Clostridioides difficile co-infection: An observational study. eCollection 2022. Your California Privacy Rights. doi: 10.1016/j.jaad.2020.04.094, 8. Got an extremely itchy rash that came seemingly out of nowhere? Pityriasis lichenoides is a clonal T-cell disorder that may develop in response to foreign antigens (eg, infections or drugs) and may be associated with cutaneous T-cell lymphoma. Disclaimer. It said blood spots under the skin might also be present, either as spots or dots or on larger areas. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Interventions: In darker-skinned or Black people, the patches may be more raised (papular), and the centers of the patches may look like the tissue is dying (necrotic). doi: 10.1111/jdv.12942, 13. Lasers Med Sci. eCollection 2022. You may develop a raised, discolored, circular or oval-shaped patch that ranges from 1 to 6 centimeters (cm). Published by Elsevier Inc. Pityriasis rosea. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291919/). Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A These strains of the herpes virus arent related to the strains that cause cold sores or genital herpes. 2023 Cond Nast. The available COVID-19 vaccines entail different levels of risk for skin reactions. Federal government websites often end in .gov or .mil. 2021 Aug;185(2):e34. Human herpesviruses 6 and 7 are common. 2005;124(6):12341240. Most of the rare, severe allergic reactions to these vaccines have occurred in people with a history of allergies. *Correspondence: Poonkiat Suchonwanit, poonkiat@hotmail.com, ORCID: Kanchana Leerunyakul orcid.org/0000-0002-0669-5611Kallapan Pakornphadungsit orcid.org/0000-0003-4783-0282Poonkiat Suchonwanit orcid.org/0000-0001-9723-0563, COVID-19 Associated Cutaneous Manifestations and COVID-19 Vaccine Related Skin Reactions, View all
Pityriasis rosea developing after COVID-19 vaccination. Skin Reactions After COVID-19 Vaccination Have Six Patterns - Medscape Int J Dermatol. 2022 Feb 20;14(2):e22414. These types cannot cause cold sores or genital herpes. (2017) 5:20311. If you have pityriasis rosea, the rash with go away without treatment. The https:// ensures that you are connecting to the . JAAD Case Rep 2018; 4: 800801. However, adverse effects to COVID-19 vaccines, particularly cutaneous reactions, have been reported. The rash itself usually doesnt blister or bleed, but in many cases, the skin may peel. With COVID-19 vaccines being authorized for emergency use, monitoring for potential adverse effects (e.g., cutaneous reactions) is necessary. Moreover, almost all lesions faded with associated post-inflammatory hyperpigmentation (Figure 2B). 2022 Oct 4;15:2117-2127. doi: 10.2147/CCID.S371630. COVID-19; SARS-CoV-2; pityriasis rosea; vaccination. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. Unauthorized use of these marks is strictly prohibited. For instance, the rash sometimes appears only under the arms or on the flanks. Accessibility Factors affecting the severity of central centrifugal cicatricial alopecia. The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s. Pityriasis Rosea Following Pfizer-BioNTech Vaccination in an Adolescent Girl. Dermatol Res Pract. Careers. Clipboard, Search History, and several other advanced features are temporarily unavailable. At first, I thought it was a mosquito bite. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Pityriasis rosea - Diagnosis and treatment - Mayo Clinic We present two cases of COVID-19 vaccine-induced pityriasis rosea. No use, distribution or reproduction is permitted which does not comply with these terms. Pityriasis rosea Gibert type rash in an asymptomatic patient that tested positive for COVID-19. Like previously reported cutaneous eruptions associated with COVID-19 infection, these cases "raise more questions than . Pityriasis means scaly, and rosea means pink, but the rashes may look red, gray, brown or purple. Following the national COVID-19 vaccination guidelines, she received a shot of ChAdOx1 nCoV-19 (AZD1222) vaccine before the therapy. Coronavirus: Five skin conditions linked to COVID-19 after - 9News Table 1. These skin conditions can include, among other things, hives, measles-like rashes and a full body rash similar to pityriasis rosea. Atzori L, Pinna AL, Ferreli C, Aste N. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center.