Environmental toxicology and chemistry, 38 10, 2087-2100, Kessler, Thorsten; Wolf, Bernhard; Eriksson, Niclas; Kofink, Daniel; Mahmoodi, Bakhtawar K; Rai, Himanshu; Tragante, Vinicius; kerblom, Axel; Becker, Richard C; Bernlochner, Isabell; Bopp, Roman; James, Stefan; Katus, Hugo A; Mayer, Katharina; Munz, Matthias; Nordio, Francesco; O'Donoghue, Michelle L; Sager, Hendrik B; Sibbing, Dirk; Solakov, Linda; Storey, Robert F; Wobst, Jana; Asselbergs, Folkert W; Byrne, Robert A; Erdmann, Jeanette; Koenig, Wolfgang; Laugwitz, Karl-Ludwig; Ten Berg, Jurrien M; Wallentin, Lars; Kastrati, Adnan; Schunkert, Heribert 2019. Board Certifications: Hematology, Internal Medicine and Medical Oncology. Clinical chemistry, 59 9, 1369-75, Becker, Richard C 2013. Thrombosis and haemostasis, 106 4, 572-84, Fox, Keith A A; Piccini, Jonathan P; Wojdyla, Daniel; Becker, Richard C; Halperin, Jonathan L; Nessel, Christopher C; Paolini, John F; Hankey, Graeme J; Mahaffey, Kenneth W; Patel, Manesh R; Singer, Daniel E; Califf, Robert M 2011. This provider currently accepts 46 insurance plans including Medicare and Medicaid. The rapid proliferation of solicited content online journals: a quest to disseminate knowledge? SPECIALTIES: General Urology and Urologic Oncology. Regulatory toxicology and pharmacology : RTP, 71 3, 398-408, Becker, Richard A; Patlewicz, Grace; Simon, Ted W; Rowlands, J Craig; Budinsky, Robert A 2015. Journal of thrombosis and thrombolysis, 35 1, 48-56, Mahaffey, Kenneth W; Wojdyla, Daniel; Hankey, Graeme J; White, Harvey D; Nessel, Christopher C; Piccini, Jonathan P; Patel, Manesh R; Berkowitz, Scott D; Becker, Richard C; Halperin, Jonathan L; Singer, Daniel E; Califf, Robert M; Fox, Keith A A; Breithardt, Gnter; Hacke, Werner 2013. 15. The family goes to the vineyard once a week to meet and make decisions. Slam.canoe.ca. Utilizing Threshold of Toxicological Concern (TTC) with High Throughput Exposure Predictions (HTE) as a Risk-Based Prioritization Approach for thousands of chemicals. A North-American perspective. Oral anticoagulants in older adults with atrial fibrillation. Outcomes of temporary interruption of rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: results from the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation (ROCKET AF). Report of an ISRTP Workshop: Progress and barriers to incorporating alternative toxicological methods in the U.S. Richard A. Becker, Christopher J. Borgert, Simon Webb, Jay Ansell, Sara Amundson, Christopher J. Portier, Alan M. Goldberg, L.H. Pathologist Richard Ablin . Thrombosis and haemostasis, 116 6, 1079-1088, Breithardt, Gnter; Baumgartner, Helmut; Berkowitz, Scott D; Hellkamp, Anne S; Piccini, Jonathan P; Lokhnygina, Yuliya; Halperin, Jonathan L; Singer, Daniel E; Hankey, Graeme J; Hacke, Werner; Becker, Richard C; Nessel, Christopher C; Mahaffey, Kenneth W; Califf, Robert M; Fox, Keith A A; Patel, Manesh R 2016. Arteriosclerosis, thrombosis, and vascular biology, 39 11, 2402-2410, Arif, Mohammed; Sadayappan, Sakthivel; Becker, Richard C; Martin, Lisa J; Urbina, Elaine M 2019. by Russell L. Blaylock MD Hardcover. Vascular Smooth Muscle Cells in Aortic Aneurysm: From Genetics to Mechanisms. Acute cardiovascular care, , 2048872617703065, Sun, Julia L; Boyle, Stephen H; Samad, Zainab; Babyak, Michael A; Wilson, Jennifer L; Kuhn, Cynthia; Becker, Richard C; Ortel, Thomas L; Williams, Redford B; Rogers, Joseph G; O'Connor, Christopher M; Velazquez, Eric J; Jiang, Wei 2017. He graduated from University of Texas Medical School At San Antonio in 1971. Transitioning to and from the novel oral anticoagulants: a management strategy for clinicians. Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence. Journal of thrombosis and thrombolysis, , Brummett, Beverly H; Babyak, Michael A; Jiang, Rong; Shah, Svati H; Becker, Richard C; Haynes, Carol; Chryst-Ladd, Megan; Craig, Damian M; Hauser, Elizabeth R; Siegler, Ilene C; Kuhn, Cynthia M; Singh, Abanish; Williams, Redford B 2013. Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial. Heart rhythm : the official journal of the Heart Rhythm Society, 11 6, 925-32, Steinhubl, Steven R; Eikelboom, John W; Hylek, Elaine M; Dauerman, Harold L; Smyth, Susan S; Becker, Richard C 2014. The American journal of medicine, 129 5 Suppl, S1-S29, Shah, Rohan; Hellkamp, Anne; Lokhnygina, Yuliya; Becker, Richard C; Berkowitz, Scott D; Breithardt, Gnter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Fox, Keith A A; Nessel, Christopher C; Mahaffey, Kenneth W; Piccini, Jonathan P; Singer, Daniel E; Patel, Manesh R 2016. And everyone who visits First Urology will enjoy the peace of mind that comes with choosing professional physicians who have years of experience here in Louisville and southern Indiana. He graduated from UNIVERSITY OF CINCINNATI / MAIN CAMPUS in 1982. Rivaroxaban for stroke prevention in East Asian patients from the ROCKET AF trial. Recommendations for further revisions to improve the International Agency for Research on Cancer (IARC) Monograph program. Regulatory toxicology and pharmacology : RTP, 90 , 185-196, Becker, Richard C 2017. Journal of thrombosis and thrombolysis, 51 3, 587-594, Becker, Richard C; Bode, Christoph 2021. The study found 38 percent fewer prostate cancer deaths among men randomly assigned to the surgery group versus those in what the Swedes called the watchful-waiting group. See all conditions on Dr. Becker's, Best Hospitals for Diabetes & Endocrinology, Lilly Plans to Slash Some Insulin Prices, Expand Cost Cap. Hypertension (Dallas, Tex. Higher risk of death and stroke in patients with persistent vs. paroxysmal atrial fibrillation: results from the ROCKET-AF Trial. Designing Human InVitro Models for Drug Development. : 1979), 77 6, 1857-1866, Ugowe, Francis E; Hellkamp, Anne S; Wang, Allen; Becker, Richard C; Berkowitz, Scott D; Breithardt, Gnter; Fox, Keith A A; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Nessel, Christopher C; Singer, Daniel E; Patel, Manesh R; Piccini, Jonathan P 2021. PloS one, 8 12, e82781. Journal of thrombosis and thrombolysis, 45 2, 197-199, Becker, Richard C; Sexton, Travis; Smyth, Susan S 2018. Lancet (London, England), 396 10253, 759-769, Sauer, Ursula G; Barter, Robert A; Becker, Richard A; Benfenati, Emilio; Berggren, Elisabet; Hubesch, Bruno; Hollnagel, Heli M; Inawaka, Kunifumi; Keene, Athena M; Mayer, Philipp; Plotzke, Kathleen; Skoglund, Robert; Albert, Ocane 2020. Translation and Clinical Development of Antithrombotic Aptamers. Jackson, Larry R; Becker, Richard C 2013. Richard DE, et al . Arteriosclerosis, thrombosis, and vascular biology, 30 3, 369-71, Povsic, Thomas J; Sullenger, Bruce A; Zelenkofske, Steven L; Rusconi, Christopher P; Becker, Richard C 2010. Selective Serotonin Reuptake Inhibitors and Bleeding Risk in Anticoagulated Patients With Atrial Fibrillation: An Analysis From the ROCKET AF Trial. Add Your Health With Dr. Richard . Scientific reports, 10 1, 6169, Becker, Richard C 2020. Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Richard A. Becker, Laura M. Plunkett, Joseph F. Borzelleca, A. Michael Kaplan. The TRACER Pharmacodynamic Substudy. Circulation, 129 21, 2088-90. Regulatory toxicology and pharmacology : RTP, 71 3, 463-77. Journal of thrombosis and thrombolysis, 37 3, 372-9, Ahmad, Tariq; Becker, Richard C 2014. Tue. Choice of agents to limit the coagulation cascade in acute coronary syndromes. Aspirin exposure reveals novel genes associated with platelet function and cardiovascular events. Martin L. Stephens, Melvin E. Andersen, Richard A. Becker, Kellyn Betts, Kim Boekelheide, E. W. Carney, Robert E. Chapin, Dennis Devlin, Suzanne Fitzpatrick, John R. Fowle, Patricia Harlow, Thomas Hartung, Sebastian Hoffmann, Michael P. Holsapple, Abigail Jacobs, Richard S. Judson, Olga Naidenko, Tim Pastoor, Grace Patlewicz, Andrew N. Rowan, Roberta W. Scherer, Rashid Shaikh, Ted W. Simon, Douglas C. Wolf, Joanne Zurlo, Development of Screening Tools for the Interpretation of Chemical Biomonitoring Data, Richard A. Becker, Sean M. Hays, Steven Robison, Lesa L. Aylward, Interlaboratory Study Comparison of the 15Day Intact Adult Male Rat Screening Assay: Evaluation of an Antithyroid Chemical and a Negative Control Chemical, Richard A. Becker, Don R. Bergfelt, Susan J. Borghoff, Jeffrey Davis, Bonnie Hamby, John C. O'Connor, A. Michael Kaplan, Carol Sloan, Rochelle W. Tyl, Michael G. Wade, Mary Sue Marty, Hypothesis-driven weight of evidence framework for evaluating data within the US EPAs Endocrine Disruptor Screening Program, Christopher J. Borgert, Ellen Mihaich, Lisa S. Ortego, Karin S. Bentley, Catherine M. Holmes, Steven L. Levine, Richard A. Becker. Inflammation and coronary artery disease: from pathophysiology to Canakinumab Anti-Inflammatory Thrombosis Outcomes Study (CANTOS). Journal of thrombosis and thrombolysis, 32 1, 125-8, Faxon, David P; Eikelboom, John W; Berger, Peter B; Holmes, David R; Bhatt, Deepak L; Moliterno, David J; Becker, Richard C; Angiolillo, Dominick J 2011. Prostate cancer may get a lot of press, but consider the numbers . Preparing for your first cancer appointment can be overwhelming. General Endocrinology + 3 more subspecialties. Reports have shown that -glucans exert multiple effects on cancer cells and cancer prevention. Cardiovascular Risk Factors and Target Organ Damage in Adolescents: The SHIP AHOY Study. Pediatric and Adult Ambulatory Blood Pressure Thresholds and Blood Pressure Load as Predictors of Left Ventricular Hypertrophy in Adolescents. Kumar, Mohit; Thangavel, Chellappagounder; Becker, Richard C; Sadayappan, Sakthivel 2020. Assessment of margin of exposure based on biomarkers in blood: an exploratory analysis. Cell reports. Antithrombotic Therapy in Atrial Fibrillation and Coronary Artery Disease. Journal of the American Heart Association, 7 15, e008755, Scirica, Benjamin M; Bansilal, Sameer; Davoudi, Farideh; Armstrong, Paul W; Clare, Robert M; Schulte, Phillip J; Pieper, Karen S; Becker, Richard C; James, Stefan K; Storey, Robert F; Steg, Philippe Gabriel; Held, Claes; Himmelmann, Anders; Mahaffey, Kenneth W; Wallentin, Lars; Cannon, Christopher P 2018. G-protein-coupled receptors as signaling targets for antiplatelet therapy. Elite Reviewers 2019. Arteriosclerosis, thrombosis, and vascular biology, 30 12, 2372-84, Woodruff, Becky; Sullenger, Bruce; Becker, Richard C 2010. Sex differences in platelet reactivity and cardiovascular and psychological response to mental stress in patients with stable ischemic heart disease: insights from the REMIT study. 10:30 am Christchurch Merivale Support Group. Quality of care & clinical outcomes, 5 2, 145-152, Gouin, Todd; Becker, Richard A; Collot, Anne-Gaelle; Davis, John W; Howard, Brett; Inawaka, Kunifumi; Lampi, Mark; Ramon, Blanca Serrano; Shi, Jay; Hopp, Philipp W 2019. New study suggests a drop in screening may have played a role. Journal of thrombosis and thrombolysis, , Becker, Richard C; Helmy, Tarek 2015. Patlewicz, G.,Ball, N.,Becker, R. A.,Booth, E. D.,Cronin, M. T.,Kroese, D.,Steup, D.,van Ravenzwaay, B.,Hartung, T. Experimental acute lead encephalopathy in the juvenile rhesus monkey. Cardiac tamponade in the fibrinolytic era: analysis of >100,000 patients with ST-segment elevation myocardial infarction. Arteriosclerosis, thrombosis, and vascular biology, 39 2, 294-302, Ungar, Leo; Rodriguez, Fatima; Hellkamp, Anne S; Becker, Richard C; Berkowitz, Scott D; Breithardt, Guenter; Fox, Keith A A; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Nessel, Christopher C; Singer, Daniel E; Patel, Manesh R; Piccini, Jonathan P; Mahaffey, Kenneth W 2019. Editor's page. The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor. Journal of thrombosis and thrombolysis, 52 4, 1010-1019, Blumer, Vanessa; Rivera, Manuel; Corbaln, Ramn; Becker, Richard C; Berkowitz, Scott D; Breithardt, Gnter; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Mahaffey, Kenneth W; Nessel, Christopher C; Piccini, Jonathan P; Hellkamp, Anne S; Singer, Daniel E; Fox, Keith A A; Patel, Manesh R 2021. Neurosurgery clinics of North America, 29 4, 503-515, Hamdani, Gilad; Flynn, Joseph T; Becker, Richard C; Daniels, Stephen R; Falkner, Bonita; Hanevold, Coral D; Ingelfinger, Julie R; Lande, Marc B; Martin, Lisa J; Meyers, Kevin E; Mitsnefes, Mark; Rosner, Bernard; Samuels, Joshua A; Urbina, Elaine M 2018. Journal of thrombosis and thrombolysis, , Muntner, Paul; Becker, Richard C; Calhoun, David; Chen, Daian; Cowley, Allen W; Flynn, Joseph T; Grobe, Justin L; Kidambi, Srividya; Kotchen, Theodore A; Lackland, Daniel T; Leslie, Kimberly K; Li, Yingchuan; Liang, Mingyu; Lloyd, Augusta; Mattson, David L; Mendizabal, Brenda; Mitsnefes, Mark; Nair, Anand; Pierce, Gary L; Pollock, Jennifer S; Safford, Monika M; Santillan, Mark K; Sigmund, Curt D; Thomas, Stephen J; Urbina, Elaine M 2016. is an endocrinologist in San Antonio, TX specializing in adult endocrinology. Dr. Blaylock discusses his book 'Natural Strategies For Cancer Patients' and offers crucial advice for . Richard and Cindy Becker. Evolution of the coronary care unit: clinical characteristics and temporal trends in healthcare delivery and outcomes. Cardiology, 9 7, 392-401, Wisler, James W; Washam, Jeffrey B; Becker, Richard C 2012. He utilizes his expertise in immunotherapy to advance treatment options. Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis. He is a medical oncologist, an associate professor at UW Medicine and an affiliate member of the Clinical Research Division of Fred Hutch. Regulatory toxicology and pharmacology : RTP, 113 , 104639, Gregersen, Ida; Michelsen, Annika E; Lunde, Ngoc Nguyen; kerblom, Axel; Lakic, Tatevik G; Skjelland, Mona; Ryeng Skagen, Karolina; Becker, Richard C; Lindbck, Johan; Himmelmann, Anders; Solberg, Rigmor; Johansen, Harald T; James, Stefan K; Siegbahn, Agneta; Storey, Robert F; Kontny, Frederic; Aukrust, Pl; Ueland, Thor; Wallentin, Lars; Halvorsen, Bente 2020. 21st Century Approaches for Evaluating Exposures, Biological Activity, and Risks of Complex Substances: Workshop highlights. 12 april 2022 . Prediction of Ambulatory Hypertension Based on Clinic Blood Pressure Percentile in Adolescents. The case for preoperative aspirin administration in patients undergoing elective CABG: is it open or closed? Approaches for describing and communicating overall uncertainty in toxicity characterizations: U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) as a case study. Autonomic dysfunction in SARS-COV-2 infection acute and long-term implications COVID-19 editor's page series. Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa receptor-directed platelet inhibition. Beware, the ugly truth. Price, Joshua J; Urbina, Elaine M; Carlin, Kristen; Becker, Richard; Daniels, Stephen R; Falkner, Bonita E; Ferguson, Michael; Hanevold, Coral; Hooper, Stephen R; Ingelfinger, Julie R; Lande, Marc B; Martin, Lisa J; Meyers, Kevin; Mitsnefes, Mark; Rosner, Bernard; Samuels, Joshua; Flynn, Joseph T 2022. His PSA level had been normal until that time. Critical pathways in cardiology, 11 2, 55-61, Wisler, James W; Becker, Richard C 2012. Methods: Trials targeted patients on active surveillance, neoadjuvant patients . "Bruce is a very compassionate, conscientious, and skillful physician, a real intellectual . Dr. Richard Becker, MD is a endocrinology, diabetes & metabolism specialist in San Antonio, TX. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, , Samad, Zainab; Boyle, Stephen; Ersboll, Mads; Vora, Amit N; Zhang, Ye; Becker, Richard C; Williams, Redford; Kuhn, Cynthia; Ortel, Thomas L; Rogers, Joseph G; O'Connor, Christopher M; Velazquez, Eric J; Jiang, Wei 2014. Journal of thrombosis and thrombolysis, 37 2, 216, Breithardt, Gnter; Baumgartner, Helmut; Berkowitz, Scott D; Hellkamp, Anne S; Piccini, Jonathan P; Stevens, Susanna R; Lokhnygina, Yuliya; Patel, Manesh R; Halperin, Jonathan L; Singer, Daniel E; Hankey, Graeme J; Hacke, Werner; Becker, Richard C; Nessel, Christopher C; Mahaffey, Kenneth W; Fox, Keith A A; Califf, Robert M 2014. Dr. Becker's office is located at 1303 McCullough Ave Ste 374 San Antonio, TX 78212. Hypertension (Dallas, Tex. Monoclonal Antibody-Based Immunotherapy and Its Role in the Development of Cardiac Toxicity. 10:00 am. $9.99. Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention. The pharmacogenetics of antiplatelet agents: towards personalized therapy? Measurement tools and antidotes for non-vitamin K oral anticoagulants. The unbridled deception about prostate cancer began with the title of his paper. Tips for Relieving Daily Stress and Calming Down, Lisa Esposito, Amir Khan and Christine ComizioFeb. International journal of cardiology, 257 , 78-83, Becker, Richard C 2018. Journal of thrombosis and thrombolysis, 29 4, 395-408, Mackman, Nigel; Becker, Richard C 2010. How well can in vitro data predict in vivo effects of chemicals? The hydrologic model as a source of nutrient loading uncertainty in a future climate. Daland R. Juberg, Susan J. Borghoff, Richard A. Becker, Warren Casey, Thomas Hartung, Michael P. Holsapple, M. Sue Marty, Ellen Mihaich, Glen Van Der Kraak, Michael G. Wade, Catherine Willett, Melvin E. Andersen, Christopher J. Borgert, Katherine K. Coady, Michael L. Dourson, John R. Fowle, L. Earl Gray, James C. Lamb, Lisa S. Ortego, Thaddeus T. Schug, Colleen Toole, Leah M. Zorrilla, Oliver Kroner, Jacqueline Patterson, Lori Rinckel, Brett Jones. JACC. Instruments for assessing risk of bias and other methodological criteria of animal studies: omission of well-established methods. Journal of thrombosis and thrombolysis, 32 1, 9-20, Xu, Weixian; Wang, Tracy Y; Becker, Richard C 2011. Aspirin dosing in cardiovascular disease prevention and management: an update. Journal of the American College of Cardiology, 52 21, 1693-701, Chan, Mark Y; Becker, Richard C; Harrington, Robert A; Peterson, Eric D; Armstrong, Paul W; White, Harvey; Fox, Keith A A; Ohman, E Magnus; Roe, Matthew T 2008. No misrepresentation of vital status follow-up in PLATO: Predefined analyses guarantee the integrity of the benefits of ticagrelor over clopidogrel in the PLATO trial: Commentary on: DiNicolantonio JJ, Tomek A, Misrepresentation of vital status follow-up: Challenging the integrity of the PLATO trial and the claimed mortality benefit of ticagrelor versus clopidogrel, International Journal of Cardiology, 2013 Serebruany VL. what are non deductible expenses for an s corporation; is bird poop najis islamqa; lipoma removal cost blue cross blue shield; knollwood village santa maria homes for sale Novel oral anticoagulants: pharmacology, coagulation measures, and considerations for reversal. Richard Becker, MD. Arteriosclerosis, thrombosis, and vascular biology, 29 4, 449-57, Wallentin, Lars; Becker, Richard C; Budaj, Andrzej; Cannon, Christopher P; Emanuelsson, Hkan; Held, Claes; Horrow, Jay; Husted, Steen; James, Stefan; Katus, Hugo; Mahaffey, Kenneth W; Scirica, Benjamin M; Skene, Allan; Steg, Philippe Gabriel; Storey, Robert F; Harrington, Robert A ; Freij, Anneli; Thorsn, Mona 2009. Your Health With Dr. Richard and Cindy Becker. 9:00 am. The biochemistry, enzymology and pharmacology of non-vitamin K anticoagulant drug reversal agents and antidotes. Journal of the American Heart Association, 7 2, Viswanathan, Shiv Kumar; Puckelwartz, Megan J; Mehta, Ashish; Ramachandra, Chrishan J A; Jagadeesan, Aravindakshan; Fritsche-Danielson, Regina; Bhat, Ratan V; Wong, Philip; Kandoi, Sangeetha; Schwanekamp, Jennifer A; Kuffel, Gina; Pesce, Lorenzo L; Zilliox, Michael J; Durai, U Nalla B; Verma, Rama Shanker; Molokie, Robert E; Suresh, Domodhar P; Khoury, Philip R; Thomas, Annie; Sanagala, Thriveni; Tang, Hak Chiaw; Becker, Richard C; Knll, Ralph; Shim, Winston; McNally, Elizabeth M; Sadayappan, Sakthivel 2018. Clinical chemistry, 63 2, 573-584, Lindner, Samuel M; Fordyce, Christopher B; Hellkamp, Anne S; Lokhnygina, Yuliya; Piccini, Jonathan P; Breithardt, Gnter; Mahaffey, Kenneth W; Singer, Daniel E; Hacke, Werner; Halperin, Jonathan L; Hankey, Graeme J; Berkowitz, Scott D; Nessel, Christopher C; Becker, Richard C; Fox, Keith A A; Patel, Manesh R 2017. 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